Public parking available or drop off along Arab Street, Village Hotel Bugis (Previously known as Golden Landmark Hotel)
Buses (2, 12, 32, 33, 130, 133, 133A, 520, 960, NR7) MRT (alight at Bugis MRT station)
Exosome Therapy is an innovative approach to skin rejuvenation that has been scientifically proven to boost collagen synthesis, stimulate cell production, increase elastin levels, and accelerate wound healing [1]!
Exosomes are natural nanoparticles released by almost all cells in the human body, including skin cells. They contain various biological materials such as lipids, proteins, amino acids, peptides, growth factors, and genetic material, making them a safe and trusted option for skincare.
Exosomes are typically applied topically to the skin. However, due to their nanoparticle nature, they cannot independently reach the deep skin layers.
Their effectiveness can only be realised after a medical device treatment creates microscopic wounds in the skin. These entry points allow the exosomes to be fully absorbed, reaching deep within the skin to activate its rejuvenation potential.
Exosomes come in serum or gel consistency. Think of exosomes as messengers — carrying and delivering critical information and factors to cells to defeat ageing and increase collagen for bouncy and youthful skin.
Exosome Therapy harnesses the body's natural ability to heal itself and reverse the effects of premature ageing symptoms like wrinkles, skin laxity and dehydrated skin.
When exosome is delivered deep into the skin, it jumpstarts the skin's natural healing ability, allowing it to rebuild itself from within.
As per a study published in Biomaterials Research, the authors have found that "exosomes have several abilities beneficial for skin tissue regeneration," indicating that they can significantly reduce symptoms of inflammatory skin conditions like eczema and aid in treating keloids [2].
Exosomes have the potential to be used as an anti-aging treatment for the skin due to their regenerative, anti-inflammatory properties.
Exosomes have shown promise in treating wrinkles by encouraging skin regeneration, boosting collagen synthesis, and rendering antioxidant protection.
Exosomes contain angiogenic capabilities, promoting wound healing and supplying oxygen-rich blood to organs and tissues.
Exosomes are valued in regenerative aesthetics medicine [3] and as effective anti-ageing treatments [4] because they improve the skin's healing and rejuvenation process, leading to better results after treatment.
The use of exosomes can lead to improved skin health and longevity, including noticeable enhancements in skin texture, pore size, hydration, clarity, and firmness.
Exosomes can also help reduce scars and wrinkles by decreasing skin inflammation and promoting fibroblast activity to produce collagen. Ongoing studies have shown positive outcomes that exosomes can improve hair restoration.
Regenerative aesthetics is a part of regenerative medicine that focuses on improving and revitalising the skin without surgery.
It emphasises the use of natural ingredients and advanced medical technologies to activate the body's natural healing processes, resulting in a more youthful appearance and improved long-term skin health.
Regenerative aesthetics target weakened cells that struggle to restore damaged tissue by enhancing the body's innate repair systems.
These treatments stimulate cell-to-cell communication to trigger rejuvenation and repair, countering the effects of intrinsic ageing.
Exosomes are vital in regenerative aesthetic medicine because they address the root causes of skin ageing and help maintain overall tissue balance [5].
As we get older, our skin cells deteriorate, our bodies produce fewer exosomes, and our collagen production decreases. Ageing signs such as wrinkles, sagging skin, and drooping facial features become more apparent.
Exosome Therapy replenishes exosomes in the body, rejuvenates older ones, and activates dormant skin cells. This treatment stimulates collagen and elastin synthesis, aids wound healing, and reduces pigment development.
Regenerative aesthetic treatments provide a long-term anti-aging and skin longevity strategy for patients who want to naturally improve their skin health from within.
Two popular regenerative aesthetic treatments in Singapore are radiofrequency microneedling and bio-stimulator injectables, which are minimally-invasive treatments that stimulate collagen production, improve skin texture and many more!
Radiofrequency microneedling, or collagen induction therapy, is a minimally invasive treatment. It involves using a specialised handheld device to create tiny punctures in the skin.
This device contains grids of gold-plated, surgical-grade, ultra-fine needles that penetrate the skin at depths ranging from 0.5mm to 3mm.
A burst of radiofrequency energy is transmitted through fine needles to targeted skin layers, stimulating the body's natural healing response and increasing collagen production, resulting in smoother, firmer, and more youthful-looking skin.
Bio-stimulator injectables promote collagen growth and address facial volume loss over time by rehydrating the deeper layers of the skin, resulting in skin tightening and lifting. They are also beneficial for treating scars, fine lines, skin creases, and stretch marks.
These injectables contain biostimulants that can slow down skin ageing. Biostimulants are fluids that contain collagen-stimulating ingredients and trigger the body's own self-regeneration mechanisms.
Some examples of bio-stimulator injectable brands in Singapore are Profhilo, Rejuran, Juvelook, Lenisna, and Gouri.
Skin and health benefits of Exosome Therapy include:
Exosomes contain antioxidants that impede skin ageing. They do so by shielding the skin cells from oxidative stress, which can lead to cell damage.
Exosomes reduce inflammation, promote tissue remodelling, and promote new blood formation for optimal wound healing.
Exosomes comprise growth factors and other materials that boost collagen synthesis, reducing wrinkles and plumping the skin.
Exosomes help protect and regenerate neurons to prevent neurodegenerative disorders like Alzheimer's and Parkinson's.
Exosomes can help treat autoimmune and inflammatory diseases by affecting immune cell functions, reducing inflammation, and promoting tissue repair.
Exosomes are a powerful tool for promoting tissue repair and regeneration [6]. They significantly contribute to regenerating damaged skin, bone, and cartilage.
Exosomes are instrumental in improving skin hydration. They carry molecules that enhance skin texture and plump the skin, resulting in a revitalised appearance.
Exosomes play a crucial role in reducing oxidative stress, which is an imbalance between free radicals and antioxidants in the body. This reduction leads to a youthful skin.
Cell communication and signalling take time. Patients typically notice an improvement in the appearance and texture of the skin after about two weeks post-treatment. Full results will occur between six and eight weeks, and the effect will continue building. The successive treatments complement each other, resulting in youthful and radiant skin.
Exosome therapy offers a wide range of benefits that anyone can enjoy. It can be an effective anti-ageing treatment and a way to rejuvenate the skin. This treatment can also address wrinkles and fine lines and improve uneven texture, dull complexion, acne scars, enlarged pores, and pigmentation.
Suitable patients for exosome treatment include those who:
Patients seeking non-surgical alternative solutions to effectively treat ageing signs like wrinkles, fine lines, and volume loss.
This group of patients will notice reduced skin elasticity, collagen degradation, and saggy skin. Exosome Therapy promotes collagen synthesis, supporting skin healing, and protects cells from oxidative stress.
Those are seeking a more natural approach with longer-lasting results to reverse the effects of skin ageing, as Exosome Therapy harnesses the body’s regenerative capabilities.
Exosomes possess excellent biocompatibility and minimal toxicity, making adverse reactions unlikely during or after treatment.
The results of Exosome Therapy will continue to improve over time. Gradual improvement begins two weeks after treatment, with full results visible between six and eight weeks and effects continuing to develop thereafter.
Prefer non-invasive alternatives
Patients seeking non-surgical alternative solutions to effectively treat ageing signs like wrinkles, fine lines, and volume loss.
Notice skin changes due to ageing
This group of patients will notice reduced skin elasticity, collagen degradation, and saggy skin. Exosome Therapy promotes collagen synthesis, supporting skin healing, and protects cells from oxidative stress.
Seek a more natural approach
Those are seeking a more natural approach with longer-lasting results to reverse the effects of skin ageing, as Exosome Therapy harnesses the body’s regenerative capabilities.
Have sensitive skin or allergies
Exosomes possess excellent biocompatibility and minimal toxicity, making adverse reactions unlikely during or after treatment.
Desire to achieve optimal results for skin longevity
The results of Exosome Therapy will continue to improve over time. Gradual improvement begins two weeks after treatment, with full results visible between six and eight weeks and effects continuing to develop thereafter.
Dr Ivan Puah will be performing the microneedling treatment with exosome therapy, as the RF Microneedling & Erbium Glass Laser is a registered medical device under HSA requirements and can only be operated by doctors with experience.
Dr Ivan Puah, the Medical Director of Amaris B. Clinic, holds a Graduate Diploma in Family Dermatology from NUS and boasts over 17 years of clinical experience in addressing various dermatological concerns. His proficiency encompasses the treatment of skin laxity, wrinkles, fine lines, hyperpigmentation, acne scarring, and more.
Dr Puah's knowledge and skill are further acknowledged through his appointment as a trainer-to-doctor by Merz Singapore and Allergan Singapore.
Is exosome treatment painful?
No, there should be no pain involved in Exosome Treatment.
Are exosomes the same as skin boosters?
Exosome therapy is a topical application of serum after a skin treatment that uses a medical device, while skin boosters are injectables.
Can I undergo exosome therapy without microneedling?
Based on your skin condition and needs, the doctor will be able to advise you on the best treatment plan, such as using lasers or microdermabrasion instead of microneedling.
How soon can I wash my face after exosomes treatment?
In general, it is best to wash your face after at least 4 hours of treatment. Your doctor will advise you accordingly.
How often must I do the treatment?
Exosome Therapy should be done every fortnight or 4 weeks, depending on your skin condition and treatment needs.
How long does it take for exosomes to start working?
You can expect to experience the effects and potential relief within a month of the treatment.
Is Exosome Therapy permanent?
Exosome Therapy has the potential to provide long-lasting results. Their effects include stimulating dormant hair follicles, which can lead to lasting benefits. Post-treatment, the exosomes remain active for about eight months.
How long do the results from Exosome Therapy last?
On average, the results from Exosome Therapy last between six and eight months.
Is there any downtime?
There is no downtime per se, but wait at least 4 hours before washing your face and applying your daily skincare products, and wait 7 days before getting a facial. As a matter of fact, Exosome Therapy can actually speed up recovery time, increase the effectiveness of the skin procedure, and reduce the number of skin treatments needed.
What activities to avoid after Exosome Therapy?
After undergoing Exosome Therapy, it's important to avoid strenuous activities for 1 to 2 days. You should wait at least a month before resuming intense workouts such as weight lifting, running, and cardio, or until instructed by your doctor. We recommend that you refrain from taking anti-inflammatory medications like ibuprofen or naproxen for three weeks following the treatment.
How much does Exosome Therapy cost in Singapore?
Every body and skin is unique, and so are your treatment plans. For the most accurate pricing of Exosome Therapy in Singapore, schedule an appointment with Dr Ivan Puah.
Reference
[1] Ash M, Zibitt M, Shauly O, Menon A, Losken A, Gould D. The Innovative and Evolving Landscape of Topical Exosome and Peptide Therapies: A Systematic Review of the Available Literature. Aesthet Surg J Open Forum. 2024 Mar 19;6:ojae017. doi: 10.1093/asjof/ojae017. PMID: 38633728; PMCID: PMC11023079.
[2] Yang, G. H., Lee, Y. B., Kang, D., Choi, E., Nam, Y., Lee, K. H., ... & Jeon, H. (2021). Overcome the barriers of the skin: exosome therapy. Biomaterials Research, 25(1), 22.
[3] Olumesi, K. R., & Goldberg, D. J. (2023). A review of exosomes and their application in cutaneous medical aesthetics. Journal of Cosmetic Dermatology, 22(10), 2628-2634.
[4] Hajialiasgary Najafabadi, A., Soheilifar, M. H., & Masoudi-Khoram, N. (2024). Exosomes in skin photoaging: biological functions and therapeutic opportunity. Cell Communication and Signaling, 22(1), 32.
[5] Vyas, K. S., Kaufman, J., Munavalli, G. S., Robertson, K., Behfar, A., & Wyles, S. P. (2023). Exosomes: the latest in regenerative aesthetics. Regenerative Medicine, 18(2), 181-194.
[6] Lu, Y., Mai, Z., Cui, L. et al. Engineering exosomes and biomaterial-assisted exosomes as therapeutic carriers for bone regeneration. Stem Cell Res Ther 14, 55 (2023). https://doi.org/10.1186/s13287-023-03275-x
Dr Ivan Puah's novel 360° Glandular Tissue Dissection (360°GTD®) technique minimises surgical invasiveness while achieving cosmetic results.
Dr Ivan Puah's novel 360° Glandular Tissue Dissection (360°GTD®) technique minimises surgical invasiveness while achieving cosmetic results.
Dr Ivan Puah's novel 360° Glandular Tissue Dissection (360°GTD®) technique minimises surgical invasiveness while achieving cosmetic results.
